The importance of dielectric constant for drug solubility prediction in binary solvent mixtures: electrolytes and zwitterions in water + ethanol.
作者信息
Abolghassemi Fakhree Mohammad Amin, Delgado Daniel R, Martínez Fleming, Jouyban Abolghasem
机构信息
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran.
出版信息
AAPS PharmSciTech. 2010 Dec;11(4):1726-9. doi: 10.1208/s12249-010-9552-3. Epub 2010 Dec 4.
Abstract
摘要
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In silico prediction of drug solubility in water-ethanol mixtures using Jouyban-Acree model.使用Jouyban-Acree模型对药物在水-乙醇混合物中的溶解度进行计算机模拟预测。
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J Pharm Sci. 1984 Feb;73(2):179-88. doi: 10.1002/jps.2600730210.
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