Department of Radiology, Division of Neuroradiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
J Neurooncol. 2011 Aug;104(1):261-9. doi: 10.1007/s11060-010-0477-1. Epub 2010 Dec 5.
While the prognosis of patients with glioblastoma (GBM) remains poor despite recent therapeutic advances, variable survival times suggest wide variation in tumor biology and an opportunity for stratified intervention. We used volumetric analysis and morphometrics to measure the spatial relationship between subventricular zone (SVZ) proximity and survival in a cohort of 39 newly diagnosed GBM patients. We collected T2-weighted and gadolinium-enhanced T1-weighted magnetic resonance images (MRI) at pre-operative, post-operative, pre-radiation therapy, and post-radiation therapy time points, measured tumor volumes and distances to the SVZ, and collected clinical data. Univariate and multivariate Cox regression showed that tumors involving the SVZ and tumor growth rate during radiation therapy were independent predictors of shorter progression-free and overall survival. These results suggest that GBMs in close proximity to the ependymal surface of the ventricles convey a worse prognosis-an observation that may be useful for stratifying treatment.
尽管最近的治疗进展使胶质母细胞瘤（GBM）患者的预后仍然不佳，但不同的生存时间表明肿瘤生物学存在广泛的差异，为分层干预提供了机会。我们使用体积分析和形态计量学方法，在一组 39 名新诊断的 GBM 患者中测量了侧脑室下区（SVZ）接近程度与生存之间的空间关系。我们在术前、术后、放疗前和放疗后采集 T2 加权和钆增强 T1 加权磁共振成像（MRI），测量肿瘤体积和到 SVZ 的距离，并收集临床数据。单因素和多因素 Cox 回归显示，涉及 SVZ 的肿瘤和放疗期间的肿瘤生长速度是无进展生存期和总生存期较短的独立预测因素。这些结果表明，靠近脑室表面的 GBM 预后较差——这一观察结果可能有助于分层治疗。
