Morowati Saeid, Yasini Mobin, Ranjbar Reza, Peivandi Ali Asghar, Ghadami Mohsen
Research Center for Human Genetics, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2010 Mar-Apr;48(2):123-4.
Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4-5% and characterized by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in males. The pathogenesis of ankyloglossia is not known. The authors report a family with isolated ankyloglossia inherited as an autosomal dominant or recessive trait. The identification of the defective gene(s) in these patients might reveal novel information on the pathogenesis of this disorder.
舌系带过短是一种先天性异常,患病率为4% - 5%,其特征为舌系带异常短小。由于不明原因,这种异常在男性中似乎更为常见。舌系带过短的发病机制尚不清楚。作者报告了一个家族,其中孤立性舌系带过短以常染色体显性或隐性性状遗传。确定这些患者中的缺陷基因可能会揭示有关该疾病发病机制的新信息。