恐惧诱导的抑郁遗传模型中的神经元改变：清醒动物的 fMRI 研究。
Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.
机构信息
Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01605, USA.
出版信息
Neurosci Lett. 2011 Feb 4;489(2):74-8. doi: 10.1016/j.neulet.2010.11.069. Epub 2010 Dec 4.
Abstract
Previous human imaging studies used facial stimuli to explore the potential association between depression and fear. This study aimed at investigating brain alterations in a rodent model of depression when innate fear was induced in the form of the predator odor trimethylthiazoline (TMT). Flinders sensitive line (FSL) rats, a genetic animal model of depression, and their control counterpart Flinders resistant line (FRL), were used in this functional magnetic resonance imaging (fMRI) assessment. Compared to FRL, FSL rats exhibited greater BOLD activation in the cortical amygdala and hypoactivation in the prefrontal cortex in response to TMT, suggesting cortico-amygdalar dysfunction in the depressed strain. In addition, the hyperactivation in the insular cortex in FSL rats may be the basis for enhanced neuronal responses to fear and aversion in depression. These results are evidence for the value of translational models of depression in expanding understanding of the neural circuitries sub-serving common human co-morbidities like depression and fear.
摘要
先前的人类影像学研究使用面部刺激来探索抑郁和恐惧之间潜在的关联。本研究旨在通过捕食者气味三甲基噻唑啉（TMT）的形式诱发先天恐惧，来研究抑郁的啮齿动物模型中的大脑变化。弗林德斯敏感系（FSL）大鼠，一种抑郁的遗传动物模型，及其对照弗林德斯抗性系（FRL）被用于本功能磁共振成像（fMRI）评估。与 FRL 相比，FSL 大鼠在对 TMT 的反应中表现出皮质杏仁核更大的 BOLD 激活和前额叶皮层的低激活，表明抑郁大鼠的皮质杏仁核功能障碍。此外，FSL 大鼠岛叶皮层的过度激活可能是增强对恐惧和厌恶的神经元反应的基础，在抑郁中。这些结果证明了抑郁的转化模型在扩大对共同人类共病（如抑郁和恐惧）的神经回路理解方面的价值。
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