[多西他赛作为声门和口腔局部晚期鳞状细胞癌联合治疗的组成部分]
[Docetaxel as a component in the combined therapy of locally advanced squamous cell carcinoma of the glottis and oral cavity].
作者信息
Alieva S B, Tkachev S I, Romanov I S, Zaderenko I A, Tiuliandin S A
出版信息
Vopr Onkol. 2010;56(5):597-602.
PMID:21137242
Abstract
Two modalities of chemoradiotherapy for locally advanced squamous cell cancer of oro-hypopharynx and oral cavity were compared in the treatment of 34 patients. Five-year survival after cisplatin, 5-FU, taxotere, and carboplatin plus irradiation with TTD of 68-72 Gy (group 1) was 59.5% versus 13.8% without taxotere (group 2). Relapse was in 9 cases (60%) (4 - group 1 and 5 - group 2). Post-therapeutic complication stage III-IV was 57.8% (group 1) and 48% (group 2).
摘要
在34例患者的治疗中，对局部晚期口咽和口腔鳞状细胞癌的两种放化疗方式进行了比较。顺铂、5-氟尿嘧啶、多西他赛和卡铂联合68-72Gy总治疗时间（TTD）放疗后的5年生存率，第1组为59.5%，而未使用多西他赛的第2组为13.8%。复发9例（60%）（第1组4例，第2组5例）。治疗后III-IV期并发症，第1组为57.8%，第2组为48%。
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