Barth E, Clawson J
United States Air Force, Lackland AFB, San Antonio, Tex., USA.
Case Rep Gastroenterol. 2010 Nov 23;4(3):502-509. doi: 10.1159/000322693.
Autoimmune hepatitis (AIH) is a form of chronic hepatitis of unknown etiology. It was first described in the 1950s as a form of chronic hepatitis noted in younger women. It was later termed lupoid hepatitis due to its association with autoantibodies before being named AIH in 1965. Corticosteroids and azathioprine have been the standard therapy for AIH, but due to treatment failures and toxicities from these medications, new medications are being investigated as possible treatment options. Rituximab has been used in various autoimmune disorders with good success. We report the case of a 34-year-old Caucasian woman with a history of B cell lymphoma and concurrent AIH treated with rituximab. The diagnosis of AIH was made by classic serological and histological features. The patient was initially treated with steroids but had a progression of her disease as well as suffering toxicities from the steroids. She was then given eight weeks of rituximab with good improvement in both laboratory and histological findings.
自身免疫性肝炎（AIH）是一种病因不明的慢性肝炎。它于20世纪50年代首次被描述为在年轻女性中发现的一种慢性肝炎形式。由于其与自身抗体有关，后来被称为类狼疮性肝炎，直到1965年才被命名为AIH。皮质类固醇和硫唑嘌呤一直是AIH的标准治疗方法，但由于这些药物治疗失败和毒性问题，新的药物正在作为可能的治疗选择进行研究。利妥昔单抗已被用于各种自身免疫性疾病并取得了良好效果。我们报告了一例34岁患有B细胞淋巴瘤病史且并发AIH的白人女性接受利妥昔单抗治疗的病例。AIH的诊断依据经典的血清学和组织学特征。患者最初接受类固醇治疗，但病情进展且出现了类固醇毒性反应。随后她接受了八周的利妥昔单抗治疗，实验室检查和组织学检查结果均有明显改善。
