基于肿瘤坏死因子配体的蛋白质疗法的计算设计。 - Suppr

Computational design of TNF ligand-based protein therapeutics.

作者信息

van der Sloot Almer M, Quax Wim J

机构信息

EMBL-CRG Systems Biology Program, Design of Biological Systems, Centre de Regulació Genòmica, Dr Aiguader 88, 08003, Barcelona, Spain.

出版信息

Adv Exp Med Biol. 2011;691:521-34. doi: 10.1007/978-1-4419-6612-4_54.

DOI:10.1007/978-1-4419-6612-4_54

PMID:21153357

Abstract

摘要

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Computational design of TNF ligand-based protein therapeutics.

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引用本文的文献

The design and characterization of receptor-selective APRIL variants.

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Computational design of TNF ligand-based protein therapeutics.

作者信息

van der Sloot Almer M, Quax Wim J

机构信息

EMBL-CRG Systems Biology Program, Design of Biological Systems, Centre de Regulació Genòmica, Dr Aiguader 88, 08003, Barcelona, Spain.

出版信息

Adv Exp Med Biol. 2011;691:521-34. doi: 10.1007/978-1-4419-6612-4_54.

DOI:10.1007/978-1-4419-6612-4_54

PMID:21153357

Abstract

摘要

相似文献

Computational design of TNF ligand-based protein therapeutics.

Adv Exp Med Biol. 2011;691:521-34. doi: 10.1007/978-1-4419-6612-4_54.

Design strategies for computational fragment-based drug design.

Methods Mol Biol. 2015;1289:137-44. doi: 10.1007/978-1-4939-2486-8_11.

Knowledge-based scoring functions in drug design: 3. A two-dimensional knowledge-based hydrogen-bonding potential for the prediction of protein-ligand interactions.

J Chem Inf Model. 2011 Nov 28;51(11):2994-3004. doi: 10.1021/ci2003939. Epub 2011 Oct 28.

[Treatment of malignant hydropericardium by intrapericardial infusion with rmhTNF].

Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):75.

Genetic engineering of death ligands for improvement of therapeutic activity.

Adv Exp Med Biol. 2011;691:507-19. doi: 10.1007/978-1-4419-6612-4_53.

Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects.

Biofactors. 2009 Jul-Aug;35(4):364-72. doi: 10.1002/biof.50.

Generalized modeling of enzyme-ligand interactions using proteochemometrics and local protein substructures.

Proteins. 2006 Nov 15;65(3):568-79. doi: 10.1002/prot.21163.

Solution of the structure of the TNF-TNFR2 complex.

Sci Signal. 2010 Nov 16;3(148):ra83. doi: 10.1126/scisignal.2000954.

Computational design of variant TNF molecules: a novel methodology for inhibition of proinflammatory cascades.

Sci STKE. 2003 Nov 11;2003(208):PE51. doi: 10.1126/stke.2003.208.pe51.

Ligand-K* Sequence Elimination: A Novel Algorithm for Ensemble-Based Redesign of Receptor-Ligand Binding.

IEEE/ACM Trans Comput Biol Bioinform. 2014 May-Jun;11(3):573-8. doi: 10.1109/TCBB.2014.2302795.

引用本文的文献

The design and characterization of receptor-selective APRIL variants.

J Biol Chem. 2012 Oct 26;287(44):37434-46. doi: 10.1074/jbc.M112.406090. Epub 2012 Sep 7.

Computational design of TNF ligand-based protein therapeutics.

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Computational design of TNF ligand-based protein therapeutics.

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