Duff Kevin
Department of Neurology, University of Utah, Salt Lake City, 84108, USA.
Appl Neuropsychol. 2010 Oct;17(4):278-82. doi: 10.1080/09084282.2010.525113.
Assessing cognitive change during a single visit requires the comparison of estimated premorbid abilities and current neuropsychological functioning. Although premorbid intellect has been widely examined, estimating premorbid memory abilities has received less attention. The current study used demographic variables and an estimate of premorbid intellect to predict premorbid memory abilities in a sample of 95 community-dwelling, cognitively intact older adults. These prediction formulas were then applied to a sample of 74 individuals with amnestic Mild Cognitive Impairment to look for discrepancies between premorbid and current memory abilities. Despite minimal differences between premorbid and current memory abilities in the intact sample, large and statistically significant differences were observed in the impaired sample. Although validation in larger samples is needed, the current estimates of premorbid memory abilities may aid clinicians in determining change across time.
在单次就诊期间评估认知变化需要比较预估的病前能力和当前的神经心理功能。虽然病前智力已得到广泛研究，但预估病前记忆能力却较少受到关注。本研究使用人口统计学变量和病前智力估计值来预测95名居住在社区、认知功能正常的老年人样本中的病前记忆能力。然后将这些预测公式应用于74名遗忘型轻度认知障碍患者样本，以寻找病前和当前记忆能力之间的差异。尽管在认知功能正常的样本中病前和当前记忆能力差异极小，但在受损样本中观察到了巨大且具有统计学意义的差异。虽然需要在更大样本中进行验证，但当前对病前记忆能力的估计可能有助于临床医生确定随时间的变化。
