Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA.
Dev Neurobiol. 2011 Jan 1;71(1):10-7. doi: 10.1002/dneu.20857.
GABAergic interneurons influence the development and function of the cerebral cortex through the actions of a variety of subtypes. Despite the relevance to cortical function and dysfunction, including seizure disorders and neuropsychiatric illnesses, the molecular determinants of interneuron fate remain largely unidentified. Challenges to this endeavor include the difficulty of studying fate determination of cells that even in rodents do not fully mature until weeks after their embryonic birth. However, in recent years a strong literature has grown on the temporal and spatial origins of distinct interneuron groups and types. Here we seek to highlight these findings, particularly in mice. Our goal is to lay the groundwork for future studies that use mouse genetics to study cortical interneuron fate determination and function.
GABA 能中间神经元通过多种亚型的作用影响大脑皮层的发育和功能。尽管与皮层功能和功能障碍有关，包括癫痫发作障碍和神经精神疾病，但中间神经元命运的分子决定因素在很大程度上仍未确定。这项工作的挑战包括研究即使在啮齿动物中，其胚胎出生后数周才完全成熟的细胞的命运决定也很困难。然而，近年来，关于不同中间神经元群体和类型的时空起源的大量文献已经出现。在这里，我们试图强调这些发现，特别是在小鼠中。我们的目标是为未来使用小鼠遗传学研究皮层中间神经元命运决定和功能的研究奠定基础。
