Liu Jia-ying, Yang Zeng-ren, Sun Fang-ren, Yan Pei-hua, Shan Qiu-ling, Li Yu-qing
Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):375-8.
In order to study airway rewarming method and rewarming devices for hypothermia, hypothermic dog model was established.
The anesthetized dog was immersed in cold water at 16.7 degrees C until the esophageal temperature (Te) of the dog decreased to 34.0 degrees C, the core temperature and skin temperature were monitored by using a 12-channel scanning thermometers. Atracurium besylate, a skeletal muscle relaxant, was injected intravenously when the core temperature of the dog was basically steady after the dog was out of the cold water, the hypothermic dog model was established.
Rectal and esophageal temperature could stand for the core temperature of the hypothermic dog model, but mixing with each other was prohibited because of leading to mistakes. Administering of atracurium besylate could eliminate the effect of shivering on airway rewarming alone, hypothermic dog model in which shivering was inhibited could be used in determination of airway rewarming technique and rewarming devices for hypothermia.
Hypothermic dog model in which shivering was inhibited can abolish the interference of shivering, experimental repeatability is good, experimental method quite simple, and the model appropriate for application and dissemination.
为研究低温时气道复温方法及复温装置，建立了低温犬模型。
将麻醉后的犬浸入16.7℃冷水中，直至犬的食管温度（Te）降至34.0℃，用12通道扫描温度计监测核心温度和皮肤温度。犬出冷水后，当核心温度基本稳定时静脉注射骨骼肌松弛剂阿曲库铵，建立低温犬模型。
直肠温度和食管温度可代表低温犬模型的核心温度，但因会导致误差，二者不能相互混用。单独给予阿曲库铵可消除寒战对气道复温的影响，可利用抑制寒战的低温犬模型来测定低温时的气道复温技术及复温装置。
抑制寒战的低温犬模型可消除寒战干扰，实验重复性好，实验方法简便，该模型适合推广应用。
