胰腺癌：研究抗凝剂治疗效果的典范癌症。
Pancreatic cancer: A model cancer for the study of the therapeutic effects of anticoagulants.
机构信息
Anthony Maraveyas, The Queen's Centre for Oncology and Haematology, Hull and York Medical School, Castle Hill Hospital, Castle Road, Hull, HU16 5JQ, United Kingdom.
出版信息
World J Gastrointest Oncol. 2009 Oct 15;1(1):38-40. doi: 10.4251/wjgo.v1.i1.38.
Cancer-related thromboembolic disease is a well recognized syndrome since first described by Armand Trousseau in 1865. Preventing the morbidity and mortality related to thromboembolism in these patients is becoming a priority research area with the advent of new anti-coagulants. It is only recently that randomized trials of improved quality are been undertaken to study this question. Many of these trials however are still not accounting for the heterogeneity of "cancer" in terms of anatomical site, histology, stage and treatment. This editorial review highlights why pancreatic cancer may serve as a model malignancy to study this question.
自 1865 年 Armand Trousseau 首次描述以来，癌症相关的血栓栓塞疾病是一种公认的综合征。随着新型抗凝剂的出现，预防这些患者发生与血栓栓塞相关的发病率和死亡率已成为一个优先研究领域。直到最近，才有质量更高的随机试验来研究这个问题。然而，许多这些试验仍然没有考虑到“癌症”在解剖部位、组织学、分期和治疗方面的异质性。本社论评论强调了为什么胰腺癌可以作为研究这个问题的模型恶性肿瘤。
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