Pine J K, Goldsmith P J, Ridgway D M, Cockbain A J, Farid S, Fraser S, Pollard S G, Attia M, Menon K V, Ahmad N
Department of Transplant Surgery, St James University Hospital, Leeds, West Yorkshire, United Kingdom.
Transplant Proc. 2010 Dec;42(10):3947-8. doi: 10.1016/j.transproceed.2010.09.072.
Donation after cardiac death (DCD) donors provide a valuable source of grafts for renal transplantation. They are exposed to an initial warm ischemic insult, which can affect early function. We sought to compare our initial DCD experience in renal transplantation with a case-matched donation after brain death (DBD) cohort from the same period. We included all DCD transplantations in the first 5 years of the program. A control DBD group was matched with a variety of donor and recipient factors. We demonstrated a significantly increased early dysfunction (DGF and primary nonfunction). DCD graft function was poorer than the DBD equivalent at 1- and 3-years. However, medium-term recipient and graft outcomes were comparable. DCD grafts continue to play a vital role in renal transplantation despite evidence of early graft dysfunction.
心脏死亡后器官捐献（DCD）供体为肾移植提供了宝贵的移植物来源。他们会遭受初始的热缺血损伤，这可能会影响早期功能。我们试图将我们在肾移植方面的初始DCD经验与同期病例匹配的脑死亡后器官捐献（DBD）队列进行比较。我们纳入了该项目前5年的所有DCD肾移植病例。一个对照DBD组与各种供体和受体因素进行了匹配。我们发现早期功能障碍（延迟性移植物功能恢复和原发性无功能）显著增加。DCD移植物在1年和3年时的功能比等效的DBD移植物差。然而，中期受体和移植物结局是可比的。尽管有早期移植物功能障碍的证据，DCD移植物在肾移植中继续发挥着至关重要的作用。
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