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[腮腺复发性多形性腺瘤的治疗:华沙医科大学耳鼻喉科1998年至2008年资料分析]

[Management of recurrent pleomorphic adenoma of the parotid gland: analysis of the material of Otolaryngology Department, Medical University of Warsaw between 1998 and 2008].

作者信息

Szwedowicz Paweł, Osuch-Wójcikiewicz Ewa, Bruzgielewicz Antoni, Checiński Piotr, Nyckowska Jagna, Grotthuss Marta

机构信息

Katedra i Klinika Otolaryngologii Warszawski Uniwersytet Medyczny.

出版信息

Otolaryngol Pol. 2010 Jun;64(7):50-4. doi: 10.1016/S0030-6657(10)70010-X.

DOI:10.1016/S0030-6657(10)70010-X
PMID:21171312
Abstract

OBJECTIVES

Treatment of patients with recurrent pleomorphic adenoma of the parotid gland is a challenge for a surgeon due to frequent problems with complete resection of all tumour foci while preserving continuity and function of the facial nerve. The aim of this study was to evaluate the clinical presentation and treatment results of patients with recurrent pleomorphic adenoma of the parotid gland.

MATERIALS AND METHODS

The medical records of 35 patients (25 women and 10 men) operated on (44 operations) for recurrent pleomorphic adenoma between the years 1988 and 2008 at the Otolaryngology Department, Medical University of Warsaw, were reviewed. These patients accounted for 8.9% of all patients treated for pleomorphic adenoma of the parotid gland (N=395). A retrospective analysis was performed to examine clinical features, surgical technique and facial nerve management.

RESULTS

All patients had palpable, nontender mass or masses in a parotid bed after 1 to 5 previous operations. Multifocal recurrences were present in 79.5% of cases. Median interval between initial treatment and commencement of recurrences was 6.1 (0.25-29) years. Patients with more than one recurrence were younger than patients who had only one. Malignant transformation of recurrent pleomorphic adenoma was observed in two patients (5.7%). Postoperative facial nerve paresis occurred in 15 cases. In two additional cases eradication of recurrent tumour required the facial nerve resection and reconstruction.

CONCLUSIONS

Recurrent pleomorphic adenoma occurs more often in younger patients and women. The risk of the facial nerve injury increases with each successive operation. Surgical treatment should be individualized, taking into consideration the extent of the previous surgery and the type of recurrence.

摘要

目的

腮腺多形性腺瘤复发患者的治疗对外科医生而言是一项挑战,因为在保留面神经连续性和功能的同时完整切除所有肿瘤病灶常常存在问题。本研究的目的是评估腮腺多形性腺瘤复发患者的临床表现及治疗结果。

材料与方法

回顾了1988年至2008年间在华沙医科大学耳鼻喉科接受手术(共44例手术)的35例腮腺多形性腺瘤复发患者(25例女性和10例男性)的病历。这些患者占所有腮腺多形性腺瘤治疗患者的8.9%(N = 395)。进行回顾性分析以检查临床特征、手术技术及面神经处理情况。

结果

所有患者在先前进行1至5次手术后,腮腺床可触及无痛性肿块。79.5%的病例存在多灶性复发。初次治疗与复发开始之间的中位间隔时间为6.1(0.25 - 29)年。复发不止一次的患者比仅复发一次的患者更年轻。2例患者(5.7%)出现复发多形性腺瘤恶变。术后15例出现面神经麻痹。另外2例患者根除复发性肿瘤需要切除并重建面神经。

结论

复发性多形性腺瘤在年轻患者和女性中更为常见。每次后续手术面神经损伤的风险都会增加。手术治疗应个体化,需考虑既往手术范围及复发类型。

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