基因芯片cDNA微阵列技术研究运动性疲劳小鼠脑内SCD-2和B-FABP基因表达
[Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray].
作者信息
Tang Liang, Tian Zhen-jun, Xiong Zheng-ying, Zhang Ying-qi
机构信息
Institute of Sports Biology, Shanxi Normal University, Xi'an 710062 China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 May;21(2):137-9.
AIM
By genechip cDNA microarray, the genes expressions of Stearoyl-coenzyme A desaturase (Scd-2) and brain fatty acid-binding protein (B-FABP) were studied in the central nervous system (CNS) of the mice to discuss the mechanism of exercise-induced fatigue.
METHODS
Building the model of fatigued animal and using the genechip cDNA microarray, the genes expressions were analyzed between the control group and fatigue group mice.
RESULTS
The genes expression of Scd-2 and B-FABP were obvious different in the brain of fatigued group mice than of control group.
CONCLUSION
Exercise-induced nerve center fatigue is correlated with genes expressions of lipid metabolism.
目的
通过基因芯片cDNA微阵列技术，研究硬脂酰辅酶A去饱和酶（Scd - 2）和脑脂肪酸结合蛋白（B - FABP）在小鼠中枢神经系统（CNS）中的基因表达，以探讨运动性疲劳的机制。
方法
建立疲劳动物模型，利用基因芯片cDNA微阵列技术分析对照组和疲劳组小鼠之间的基因表达。
结果
疲劳组小鼠大脑中Scd - 2和B - FABP的基因表达与对照组相比有明显差异。
结论
运动诱导的神经中枢疲劳与脂质代谢的基因表达相关。
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