着丝粒：NDC80 在线。

Kinetochores: NDC80 toes the line.

机构信息

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80525, USA.

出版信息

Curr Biol. 2010 Dec 21;20(24):R1083-5. doi: 10.1016/j.cub.2010.11.033.

DOI:10.1016/j.cub.2010.11.033

Abstract

Kinetochore-associated NDC80 complexes serve as the primary binding site for the plus-ends of spindle microtubules in mitosis. A recent study proposes a novel mechanism for regulating kinetochore-microtubule binding involving NDC80 complex oligomerization, which could be mediated by Aurora B kinase.

摘要

着丝粒相关的 NDC80 复合物是有丝分裂中纺锤体微管的正极的主要结合位点。最近的一项研究提出了一种调节着丝粒-微管结合的新机制，涉及 NDC80 复合物的寡聚化，这可能由 Aurora B 激酶介导。