基于体素的弥散张量成像检测原发性侧索硬化症中的锥体束变性。
Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis.
机构信息
Department Radiology, Medical School University of Ioannina, Greece.
出版信息
Br J Radiol. 2011 Jan;84(997):78-80. doi: 10.1259/bjr/14368804.
OBJECTIVE
Primary lateral sclerosis (PLS) is a progressive degenerative disorder affecting upper motor neurons and requires a clinical diagnosis. Diffusion tensor imaging (DTI) is a quantitative method for assessing white matter fibre integrity. The purpose of the study was to evaluate the involvement of upper motor neurons by using DTI in PLS.
METHODS
A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis.
RESULTS
Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells.
CONCLUSION
Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS.
目的
原发性侧索硬化症（PLS）是一种影响上运动神经元的进行性退行性疾病，需要临床诊断。弥散张量成像（DTI）是一种评估白质纤维完整性的定量方法。本研究旨在通过 DTI 评估 PLS 中上运动神经元的受累情况。
方法
将 PLS 患者与 8 名年龄匹配的对照组进行比较。在体素基础上使用 DTI 评估各向异性分数（FA）指数的差异。
结果
双侧锥体束近端 FA 值降低，表明锥体细胞发生变性。
结论
基于体素的 DTI 可作为检测 PLS 中运动神经元变性的客观标志物。
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