募集的炎性单核细胞在受感染组织中刺激抗病毒 Th1 免疫。
Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue.
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):284-9. doi: 10.1073/pnas.1005201108. Epub 2010 Dec 20.
Abstract
Monocytes patrol various tissues for signs of infection and inflammation. Inflammatory monocytes enter peripheral tissues at sites of microbial infection and differentiate into dendritic cells and macrophages. Here, we examined the importance of monocytes in primary mucosal infection with herpes simplex virus 2 (HSV-2), and demonstrate that monocyte-derived APCs are required to elicit IFN-γ secretion from effector Th1 cells to mediate antiviral protection. However, monocyte-derived APCs were dispensable for the generation of Th1 immunity and for the restimulation of memory Th1 cells during secondary viral challenge. These results demonstrate that distinct APC subsets are dedicated for CD4 T cell priming, elicitation, and memory recall responses to a given viral pathogen within the same mucosal tissue and reveal a specialized role for monocyte-derived APCs in the emergency response to infection.
摘要
单核细胞在各个组织中巡逻，以寻找感染和炎症的迹象。炎性单核细胞在微生物感染的部位进入外周组织，并分化为树突状细胞和巨噬细胞。在这里，我们研究了单核细胞在单纯疱疹病毒 2（HSV-2）原发性粘膜感染中的重要性，并证明单核细胞衍生的 APC 对于从效应性 Th1 细胞中诱导 IFN-γ 分泌以介导抗病毒保护是必需的。然而，单核细胞衍生的 APC 在二次病毒攻击时产生 Th1 免疫和再刺激记忆 Th1 细胞是可有可无的。这些结果表明，在同一粘膜组织中，不同的 APC 亚群专门用于 CD4 T 细胞的初始、引发和记忆召回反应，针对特定的病毒病原体，并揭示了单核细胞衍生的 APC 在感染应急反应中的特殊作用。
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