Shin Seung Min, Park Sang Man, Hwang Byung Sik, Seol Soo Hwan, Seo Hyang Eun, Kim Se Hwan, Gu Mi Jin, Shin Ji Yeol
Departments of Internal Medicine, Fatima Hospital, Daegu, Korea.
Korean J Gastroenterol. 2010 Dec;56(6):377-81. doi: 10.4166/kjg.2010.56.6.377.
Mesothelioma is a rare aggressive tumor arising from the mesothelial cell and regarded as universally fatal disease with average survival around 1 year. The incidence rate is varied from one to forty per million in different countries and increasing by the year. The most common site of tumor origin is the pleura and only 20% to 33% of mesothelioma arise from the peritoneum. There are increasing reports of malignant mesothelioma with forty to fifty fatal cases per year in Korea. Histological studies with immunohistochemical stain is helpful for the diagnosis of peritoneal mesothelioma and imaging modality alone is not sufficient for diagnosis, so it is difficult to confirm diagnosis. A 64-year-old male patient was admitted to the hospital with a palpable mass on abdomen. The 6x6 cm sized huge mass was seen on the body of stomach adjacent to the peritoneum. We report a case of malignant peritoneal mesothelioma without evident exposure to asbestos, of which direct invasion to the gastric mucosa was confirmed by endoscopic biopsy and immunohistochemical stain.
间皮瘤是一种罕见的侵袭性肿瘤,起源于间皮细胞,被视为普遍致命的疾病,平均生存期约为1年。不同国家的发病率从每百万分之一到四十不等,且逐年上升。肿瘤最常见的起源部位是胸膜,只有20%至33%的间皮瘤起源于腹膜。韩国每年有越来越多关于恶性间皮瘤的报道,每年有40至50例致命病例。组织学研究及免疫组化染色有助于腹膜间皮瘤的诊断,仅靠影像学检查不足以确诊,因此确诊困难。一名64岁男性患者因腹部可触及肿块入院。在胃体靠近腹膜处可见一个6×6厘米大小的巨大肿块。我们报告一例无明显石棉接触史的恶性腹膜间皮瘤病例,经内镜活检和免疫组化染色证实其直接侵犯胃黏膜。