红细胞脂氧合酶对线粒体膜的氧合作用。对膜性质的影响。
Oxygenation of mitochondrial membranes by the erythroid lipoxygenase. Consequences for membrane properties.
作者信息
Wiesner R, Kühn H, Anton M, Schewe T
机构信息
Institute of Biochemistry, School of Medicine (Charité), Humboldt University, Berlin, GDR.
出版信息
Biomed Biochim Acta. 1990;49(2-3):S35-8.
The reticulocyte lipoxygenase is able to oxygenate mitochondrial membranes. The main products formed during this reaction are 15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-HETE) and 13S-hydroperoxy-9Z,11E-octadecadienoic acid (13-HODE). The oxygenation of mitochondrial membranes is accompanied by an inactivation of enzymes localized in the outer and inner mitochondrial membranes, by a drastic change of the passive electric properties and by a destruction of the iron-sulfur clusters of the outer mitochondrial membrane. The possible mechanism of the processes leading to these functional changes is discussed.
网织红细胞脂氧合酶能够使线粒体膜发生氧化反应。该反应过程中形成的主要产物是15S-氢过氧-5Z,8Z,11Z,13E-二十碳四烯酸（15-HETE）和13S-氢过氧-9Z,11E-十八碳二烯酸（13-HODE）。线粒体膜的氧化反应伴随着定位于线粒体外膜和内膜的酶的失活、被动电性质的剧烈变化以及线粒体外膜铁硫簇的破坏。文中讨论了导致这些功能变化的可能机制。
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