子痫前期孕妇孕早期母血及足月胎盘组织中过氧化氢与可溶性肿瘤坏死因子-α受体2呈正相关。
A positive correlation between hydrogen peroxide and soluble TNF-alpha receptor 2 early in maternal blood and at term in placenta of pregnant women with preeclampsia.
作者信息
Leblanc Samuel, Ouellet Annie, Giguère Yves, Forest Jean-Claude, Moutquin Jean-Marie, Aris Aziz
机构信息
Department of Obstetrics-Gynecology, Sherbrooke University Hospital Centre, Sherbrooke, QC, Canada.
出版信息
Hypertens Pregnancy. 2012;31(3):357-66. doi: 10.3109/10641955.2010.525281. Epub 2010 Dec 21.
OBJECTIVES
We hypothesized that hydrogen peroxide (H(2)O(2)) and soluble TNF-α receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia.
METHODS
Correlation of H(2)O(2) and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture.
RESULTS
We showed a positive correlation between increased levels of H(2)O(2) and sTNF-R2 early at 10-15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H(2)O(2) induced the placental synthesis of sTNF-R2.
CONCLUSION
We propose to consider H(2)O(2) and sTNF-R2 as potential biomarkers in predicting preeclampsia.
目的
我们推测过氧化氢（H₂O₂）和可溶性肿瘤坏死因子-α受体2（sTNF-R2）在子痫前期的发病机制中共同发挥作用。
方法
在体内评估母体血液和胎盘以及体外滋养层细胞培养中H₂O₂与sTNF-R2的相关性。
结果
我们发现，在妊娠10 - 15周早期以及足月时，子痫前期女性的母体血清和胎盘中，H₂O₂水平升高与sTNF-R2水平升高呈正相关。我们的体外实验表明，H₂O₂可诱导胎盘合成sTNF-R2。
结论
我们建议将H₂O₂和sTNF-R2视为预测子痫前期的潜在生物标志物。
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