School of Materials Science and Engineering, Nanyang Technological University, Blk N4.1 Nanyang Avenue, Singapore 639798, Singapore.
Int J Pharm. 2011 Oct 10;418(1):28-41. doi: 10.1016/j.ijpharm.2010.12.020. Epub 2010 Dec 21.
This paper aims to provide a comprehensive review of the various models or simulations for predicting drug release from bulk-degrading systems. A brief description of bulk degradation processes and factors affecting the degradation rate, and consequently the release kinetics, is presented first. Next, several important classical models, often used as the basis for subsequent model development, are discussed. Both mathematical models and Monte-Carlo based simulations have been developed for controlled release from bulk-degrading systems. The mathematical models can be further subdivided into two categories. First, the diffusion-based models whose transport mechanism is mainly governed by diffusion, but with degradation-dependent diffusion coefficients. These are generally simpler and easier to use and are sufficient to illustrate mono-phasic release. Second, comprehensive models that combine diffusion with other theories such as erosion, drug dissolution and/or pore percolations. These models usually involve more complex equations but provide good matches for multi-phasic release profiles.
本文旨在全面综述用于预测从整体降解系统中释放药物的各种模型或模拟方法。首先简要介绍了整体降解过程以及影响降解速率进而影响释放动力学的因素。接下来，讨论了几个常用作后续模型开发基础的重要经典模型。已经开发了用于从整体降解系统中控制释放的数学模型和基于 Monte-Carlo 的模拟。数学模型可以进一步分为两类。首先，基于扩散的模型，其传输机制主要由扩散控制，但扩散系数与降解有关。这些模型通常更简单，更容易使用，足以说明单相释放。其次，综合模型将扩散与其他理论（如侵蚀、药物溶解和/或孔渗透）相结合。这些模型通常涉及更复杂的方程，但可以很好地匹配多相释放曲线。
