Lange J, Knüttgen D, Stoelben E, Bauerfeind U, Wappler F, Sakka S G
Klinik für Viszeral-, Gefäß- und Transplantationschirurgie, Klinikum der Universität Witten/Herdecke mit Sitz in Köln, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Köln, Deutschland.
Anaesthesist. 2011 Mar;60(3):230-5. doi: 10.1007/s00101-010-1801-z. Epub 2010 Dec 25.
Pumpless extracorporeal carbon dioxide elimination using the interventional lung assist (iLA) membrane ventilator is a modern concept for the treatment of hypercapnia due to respiratory failure which cannot be sufficiently treated by conventional strategies. Heparin-induced thrombocytopenia type II (HIT II) is considered to be an absolute contraindication for placement of an iLA because of the system's heparin-coated diffusion membrane. The example demonstrates that iLA therapy can be continued despite occurrence of a HIT II in terms of an "off label use". In the case described, postoperative therapy using the iLA membrane ventilator was installed in a 69-year-old patient with severe ARDS after elective lung resection. Despite a confirmed HIT II detected in the course of iLA, this therapy was continued after changing systemic anticoagulation to argatroban. The platelet count increased again and the patient could be successfully weaned from the iLA membrane and finally transferred to a rehabilitation centre.
使用介入式肺辅助(iLA)膜式呼吸机进行无泵体外二氧化碳清除是治疗因呼吸衰竭导致的高碳酸血症的一种现代理念,而传统策略对此类呼吸衰竭无法进行充分治疗。由于该系统的肝素涂层扩散膜,II型肝素诱导的血小板减少症(HIT II)被认为是放置iLA的绝对禁忌症。该案例表明,尽管出现了HIT II,但就“超说明书使用”而言,iLA治疗仍可继续。在所描述的病例中,一名69岁的患者在择期肺切除术后发生严重急性呼吸窘迫综合征(ARDS),使用iLA膜式呼吸机进行术后治疗。尽管在iLA治疗过程中确诊为HIT II,但在将全身抗凝改为阿加曲班后,该治疗仍继续进行。血小板计数再次升高,患者最终成功撤下iLA膜式呼吸机,并最终转至康复中心。