全关节置换术后骨转换标志物的血清水平。
Serum levels of bone turnover markers following total joint arthroplasty.
作者信息
Kenanidis Eustathios I, Potoupnis Michael E, Papavasillioul Kyriakos A, Sayegh Fares E, Petsatodis George E, Kapetanos George A
机构信息
3rd Orthopaedic Department, Aristotle University of Thessaloniki-Medical School, Papageorgiou General Hospital, Thessaloniki, Greece.
出版信息
J Orthop Surg (Hong Kong). 2010 Dec;18(3):290-5. doi: 10.1177/230949901001800307.
PURPOSE
To evaluate changes in serum levels of bone turnover markers during the first year following a total hip or knee arthroplasty (THA or TKA, respectively).
METHODS
34 women and 13 men (mean age, 68 years) with idiopathic hip or knee osteoarthritis underwent elective THA or TKA. The serum levels of (1) osteoprotegerin, (2) nuclear factor-kappa B ligand (RANKL), (3) osteocalcin, and (4) bone-specific alkaline phosphatase (b-ALP) were determined in each patient on preoperative day 1 and postoperative day 3 and 7, and month 2, 4, 6, 8, 10, and 12.
RESULTS
All 4 markers changed significantly over the 12-month period. At month 12, values of all markers did not return to their preoperative levels uniformly. At month 8, the serum levels of osteoprotegerin, osteocalcin, and b-ALP remained higher than their respective preoperative values. The serum levels of RANKL gradually decreased after month 2, rendering this marker a potential index for fixation.
CONCLUSIONS
Bone turnover markers change following arthroplasties. Postoperative month 8 seems to be a milestone in the normal course of these markers.
目的
评估全髋关节置换术（THA）或全膝关节置换术（TKA）后第一年血清骨转换标志物水平的变化。
方法
34名女性和13名男性（平均年龄68岁）因特发性髋或膝骨关节炎接受择期THA或TKA。在术前第1天、术后第3天和第7天以及术后第2、4、6、8、10和12个月测定每位患者的（1）骨保护素、（2）核因子-κB配体（RANKL）、（3）骨钙素和（4）骨特异性碱性磷酸酶（b-ALP）的血清水平。
结果
在12个月期间，所有4种标志物均发生了显著变化。在第12个月时，所有标志物的值并未均一性地恢复到术前水平。在第8个月时，骨保护素、骨钙素和b-ALP的血清水平仍高于各自的术前值。RANKL的血清水平在第2个月后逐渐下降，使其成为一个潜在的固定指标。
结论
关节置换术后骨转换标志物会发生变化。术后第8个月似乎是这些标志物正常变化过程中的一个里程碑。
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