靶向外源性胆固醇摄取的治疗方法：新的见解和争议。
Therapies targeting exogenous cholesterol uptake: new insights and controversies.
机构信息
Clinical Professor, Director of Preventive Cardiology, The University of Chicago Pritzker School of Medicine, 515 North State Street, Suite 2700, Chicago, IL 60654, USA.
出版信息
Curr Atheroscler Rep. 2011 Feb;13(1):95-100. doi: 10.1007/s11883-010-0151-2.
Exogenous cholesterol uptake involves a complex process in the intestines for the absorption of cholesterol and bile acids. This process is regulated by intestinal nuclear transcription factors such as LXR that affect sterol transporters NPC1L1, ABCG5/G8, and ABCG1, and enzymes such as ACAT-2. Plant sterol/stanols, ezetimibe, and bile acid sequestrants have a variety of effects on these various transporters, and new insights into their mechanism(s) of action have provided a plethora of exciting targets for metabolic diseases, dyslipidemia, and atherosclerosis.
外源性胆固醇摄取涉及肠道中胆固醇和胆汁酸的吸收的复杂过程。该过程受肠核转录因子（如 LXR）调控，影响甾醇转运蛋白 NPC1L1、ABCG5/G8 和 ABCG1，以及酶（如 ACAT-2）。植物甾醇/甾烷醇、依折麦布和胆汁酸螯合剂对这些各种转运蛋白具有多种作用，对其作用机制的新见解为代谢疾病、血脂异常和动脉粥样硬化提供了许多令人兴奋的靶点。
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