Andreyev H Jervoise N, Wotherspoon Andrew, Denham James W, Hauer-Jensen Martin
Royal Marsden Hospital, London, UK.
Scand J Gastroenterol. 2011 Apr;46(4):389-97. doi: 10.3109/00365521.2010.545832. Epub 2010 Dec 29.
Cancer therapies increasingly achieve cure, but result in chronic moderate or severe gastrointestinal side effects in millions of patients worldwide. Paradoxically, modern therapies threaten to increase the burden of chronic gastrointestinal toxicity, not reduce it.
To define pelvic radiation disease.
A reinterpretation of published data.
The lack of interest in patients with pelvic radiation disease is startling. Symptoms after radiotherapy are only a manifestation of new onset gastrointestinal physiological deficits induced by the radiotherapy. With proper diagnosis and treatment of these deficit(s), the symptoms are curable. Science suggests that much radiotherapy-induced gastrointestinal morbidity is preventable. Once the true nature of radiation injury is understood, straightforward solutions emerge and inaccurate dogmas can be discarded. Imprecise language is a fundamental barrier to progress in complex disorders.
Radiation-induced gastrointestinal toxicity is bedeviled by inappropriate terminology, causing confusion, and myth which legitimizes inappropriate clinical behavior. We must address honestly the uncomfortable reality that doctors, sometimes do harm. Not to do so in an era where survivorship is a reality, will deny millions often with severe symptoms from "pelvic radiation disease", the care which will help them.
癌症治疗越来越多地实现治愈，但在全球数百万患者中导致慢性中度或重度胃肠道副作用。矛盾的是，现代疗法有可能增加而非减轻慢性胃肠道毒性的负担。
定义盆腔放射病。
对已发表数据进行重新解读。
对盆腔放射病患者缺乏关注令人吃惊。放疗后的症状只是放疗引起的新发胃肠道生理缺陷的一种表现。对这些缺陷进行正确诊断和治疗，症状是可以治愈的。科学表明，许多放疗引起的胃肠道疾病是可以预防的。一旦了解了放射损伤的真正性质，就会出现直接的解决方案，不准确的教条也可以摒弃。不精确的语言是复杂疾病进展的根本障碍。
辐射引起的胃肠道毒性因不恰当的术语、造成的混乱以及使不恰当临床行为合理化的错误观念而受到困扰。我们必须诚实地面对医生有时会造成伤害这一令人不安的现实。在生存成为现实的时代，如果不这样做，将使数百万患有“盆腔放射病”严重症状的患者得不到有助于他们的治疗。
