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阳离子脂质体与细胞膜模型的相互作用。

Interaction of cationic liposomes with cell membrane models.

机构信息

Dipartimento di Ingegneria Chimica, dei Materiali, delle Materie Prime e dell'Ambiente, Università degli Studi di Roma Sapienza, P.le A. Moro 5, 00185 Roma, Italy.

出版信息

J Colloid Interface Sci. 2011 Mar 1;355(1):1-8. doi: 10.1016/j.jcis.2010.12.005. Epub 2010 Dec 7.

Abstract

The interaction of phosphatidylcholine liposomes used as cell models, with cationic liposomes formulated with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine and amphiphiles based on a pyrrolidinium headgroup was investigated by differential scanning calorimetry and fluorescence resonance energy transfer experiments. The results obtained showed that subtle variations in the formulation can influence lipid interactions and were correlated to a previous biological evaluation.

摘要

采用差示扫描量热法和荧光共振能量转移实验研究了作为细胞模型的磷脂双分子层囊泡与 1,2-二肉豆蔻酰-sn-甘油-3-磷酸胆碱和基于吡咯烷头基的两亲分子形成的阳离子脂质体的相互作用。结果表明,配方中的细微变化会影响脂质相互作用,并与之前的生物学评价相关。

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