[Theory and applicability of stochastic models for the development of in vitro isolated cell-populations of bone marrow].

A general model for the development of cell-populations of bone marrow, based on present knowledge of haematocytopoiesis, is derived. In evaluating the various parameters of the model (transmission probabilities etc.) two different ways wer~ involved: a) Observation of labeled cells during sub-sequent development, b) determination of the function of distribution at various time intervals by cell counting. Although the final solution of the problem is not yet possible for various reasons, however, some detailed aspects have been worked out ~uccessfully. Two attempts, i.e. the mathematical treat-ment of FlRESCU and TAUTU (Bukarest) and that of FUCHS (Berlin). will be discussed with regards to the underlying basic arguments, the practical applicability, and the limitations.