Anai H, Okada Y, Okubo K, Korenaga D, Maehara Y, Sugimachi K, Ohi Y
Department of Surgery, Shakaihoken Nakabaru Hospital.
Nihon Gan Chiryo Gakkai Shi. 1990 Jul 20;25(7):1487-91.
An autopsy case of hemolytic uremic syndrome after treatment with antineoplastic agents for advanced gastric carcinoma is reported. A 70 year-old woman underwent partial gastrectomy for gastric carcinoma on April 16, 1987 (P0H0S2N4, Stage IV). She was treated with Mitomycin C (MMC), UFT, OK-432 and PSK as post operative chemotherapy. Total doses were 60 mg of MMC, 33.9 g of UFT, 55 KE of OK-432 and (507 g) of PSK. She suffered from occult blood in urine in September 1987, thrombocytopenia and anemia in October, edema and hypertension in November and died due to acute renal failure and pulmonary failure on December 5, 1987. It seemed that the cause of death was hemolytic uremic syndrome induced by antineoplastic agents.
报告了一例晚期胃癌接受抗肿瘤药物治疗后发生溶血性尿毒症综合征的尸检病例。一名70岁女性于1987年4月16日因胃癌接受了部分胃切除术（P0H0S2N4，IV期）。术后她接受了丝裂霉素C（MMC）、优福定（UFT）、溶链菌制剂（OK-432）和云芝多糖（PSK）化疗。MMC总剂量为60mg，UFT为33.9g，OK-432为55KE，PSK为（507g）。她于1987年9月出现血尿，10月出现血小板减少和贫血，11月出现水肿和高血压，并于1987年12月5日因急性肾衰竭和肺衰竭死亡。死因似乎是抗肿瘤药物诱发的溶血性尿毒症综合征。
