Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands.
J Head Trauma Rehabil. 2011 Jan-Feb;26(1):90-7. doi: 10.1097/HTR.0b013e31820367b3.
This population study examines the prevalence of hypopituitarism and low bone mineral density (BMD) in older persons reporting loss of consciousness after head trauma (HT).
Data from the Longitudinal Aging Study Amsterdam were used pertaining to 630 women (53 HT) and 533 men (63 HT). Subjects were asked whether they had ever had an HT with loss of consciousness. Linear regression analysis (adjusted for age, body mass index, chronic diseases, smoking, alcohol use, and gender) was performed to examine the association between HT and serum anteriory pituitary hormone levels, BMD, and quantative ultrasound measurements.
Serum follicle stimulating hormone was significantly higher in males in the HT group (P = .05) than in the non-HT group. This difference was not found in women (P = .25). No other differences were observed in serum hormone levels between subjects with and without HT (P > .30). Also, no significant differences between the HT and non-HT group were found in BMD and quantitative ultrasound measurements.
A self-reported history of HT with loss of consciousness does not seem to increase the risk of hypopituitarism and lower BMD in an aging population.
本人群研究调查了报告头部创伤（HT）后意识丧失的老年人中垂体功能减退症和低骨密度（BMD）的患病率。
使用阿姆斯特丹纵向老龄化研究的数据，涉及 630 名女性（53 例 HT）和 533 名男性（63 例 HT）。询问受试者是否曾经有过 HT 伴意识丧失。进行线性回归分析（调整年龄、体重指数、慢性疾病、吸烟、饮酒和性别），以检查 HT 与血清前垂体激素水平、BMD 和定量超声测量之间的关联。
HT 组男性的血清卵泡刺激素显着高于非 HT 组（P =.05）。在女性中未发现这种差异（P =.25）。在 HT 组和非 HT 组之间，血清激素水平没有观察到其他差异（P >.30）。此外，HT 组和非 HT 组之间的 BMD 和定量超声测量也没有显着差异。
报告头部创伤后意识丧失的病史似乎不会增加老年人垂体功能减退症和低 BMD 的风险。
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