Baines Christopher P
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, University of Missouri-Columbia, 134 Research Park Drive, Columbia, MO 65211, USA.
Pediatr Cardiol. 2011 Mar;32(3):258-62. doi: 10.1007/s00246-010-9880-9. Epub 2011 Jan 6.
That apoptosis is mediated by specific pathways has long been established. However, more recent data have begun to suggest that necrosis may in fact be "programmed" and not a default "accidental" pathway as previously thought. The mitochondrial permeability transition pore, a known contributor to the development of many cardiac diseases, is emerging as one among several mediators of this necrotic program. Consequently, this report briefly reviews the roles of necrosis versus apoptosis in the pathogenesis of cardiac disease and discusses the role that the mitochondrial pore plays in cardiac necrotic cell death.
细胞凋亡由特定途径介导这一点早已得到证实。然而，最近的数据开始表明，坏死实际上可能是“程序性的”，而非如之前所认为的是一种默认的“意外”途径。线粒体通透性转换孔是许多心脏疾病发展过程中的一个已知因素，正成为这种坏死程序的几种介导因素之一。因此，本报告简要回顾了坏死与凋亡在心脏疾病发病机制中的作用，并讨论了线粒体孔在心脏坏死性细胞死亡中所起的作用。
