寄生虫获得性免疫的演变。
The evolution of acquired immunity to parasites.
作者信息
Mitchison N A
机构信息
Imperial Cancer Research Fund, University College London.
出版信息
Parasitology. 1990;100 Suppl:S27-34. doi: 10.1017/s0031182000072991.
Evolutionary pressures exerted by parasites on the immune system, and vice versa, are surveyed from a speculative viewpoint. New information is presented about the possible channelling of suppression by MHC Class II genes in the mouse, where a novel pattern of dominant unresponsiveness mediated by H-2Ab is described. In addition, the hypothesis is advanced that phosphatidyl-inositol anchorage on the surface of parasites may represent a novel evasion mechanism, in which the spread of the immune response by epitope linkage is inhibited by host phospholipase.
从推测的角度审视了寄生虫对免疫系统施加的进化压力，反之亦然。本文介绍了关于小鼠MHC II类基因可能介导抑制作用的新信息，其中描述了由H-2Ab介导的一种新的显性无反应模式。此外，还提出了一种假说，即寄生虫表面的磷脂酰肌醇锚定可能代表一种新的逃避机制，在这种机制中，宿主磷脂酶抑制了通过表位连接的免疫反应扩散。
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