前列腺特异性抗原和前列腺特异性抗原密度在前列腺癌诊断中的相对性能特征。

Relative performance characteristics of prostate specific antigen and prostatic specific antigen density for the diagnosis of carcinoma of the prostate.

作者信息

Mueller E J, Coventry J, Desmond P M, Zeidman E J, Thompson I M

机构信息

Urology Service, Department of Surgery, Brooke Army Medical Center, Trinity University, San Antonio, Texas, USA.

出版信息

Urol Oncol. 1995 Mar-Apr;1(2):84-7. doi: 10.1016/1078-1439(95)00022-a.

DOI:10.1016/1078-1439(95)00022-a

PMID:21224097

Abstract

Prostate specific antigen (PSA) has become an important method for early detection of prostate cancer. It has been suggested that prostate specific antigen density (PSAD) may be a more efficient test for early detection than PSA alone. A series of 327 men undergoing prostate biopsy were evaluated by PSA and PSAD. When the receiver operating characteristic curves of both tests were compared, they demonstrated little improvement in the efficiency of detection with the use of PSAD. The five-fold increase in the cost of PSAD over PSA alone does not justify its inclusion in a plan for early detection for carcinoma of the prostate.

摘要

前列腺特异性抗原（PSA）已成为早期检测前列腺癌的重要方法。有人提出，前列腺特异性抗原密度（PSAD）可能是比单独使用PSA更有效的早期检测方法。对327名接受前列腺活检的男性进行了PSA和PSAD评估。当比较两种检测方法的受试者工作特征曲线时，结果显示使用PSAD检测效率几乎没有提高。PSAD的成本比单独使用PSA增加了五倍，这使其纳入前列腺癌早期检测方案并不合理。