Yoneko M, Katayama Y, Moro N, Kamei J, Kojima J
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Methods Find Exp Clin Pharmacol. 2010 Dec;32(10):727-31. doi: 10.1358/mf.2010.32.10.1561078.
Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, reduces total blood volume, aggravates cerebral vasospasm and causes cerebral ischemia after SAH. This study examined the inhibitory effect of hydrocortisone on CSW in rat SAH models. Hydrocortisone had an inhibitory effect on CSW because hydrocortisone functioned in a dose-dependent manner to inhibit the increase in sodium excretion and sodium/potassium ratio after SAH onset. We conclude that hydrocortisone is a useful drug for the treatment of CSW after SAH.
脑性盐耗综合征（CSW）常与蛛网膜下腔出血（SAH）同时发生。CSW可导致钠排泄过多和渗透性利尿，减少总血容量，加重脑血管痉挛，并在SAH后引起脑缺血。本研究检测了氢化可的松对大鼠SAH模型中CSW的抑制作用。氢化可的松对CSW具有抑制作用，因为氢化可的松以剂量依赖的方式发挥作用，抑制SAH发作后钠排泄和钠/钾比值的升高。我们得出结论，氢化可的松是治疗SAH后CSW的有效药物。
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