Philip Regal is at the University of Minnesota, Minneapolis, MN 55455, USA.
Trends Ecol Evol. 1988 Apr;3(4):S36-8. doi: 10.1016/0169-5347(88)90138-3.
Most genetically engineered organisms are unlikely to pose any threat to the environment because they are already highly selected for survival under restricted conditions. Engineering for new traits in natural or semi-natural populations, however, may entail greater risks. Genetic novelty, i.e. mutation, is an important component of the evolutionary process; a small but significant proportion of natural mutations lead to improved fitness and increased competitiveness. The artificial insertion of a new trait may produce a similar effect, setting an organism on a new and unpredictable evolutionary track. The current challenge is to attain the capacity to identify the small proportion of genetically engineered organisms in which such events might occur.
大多数基因工程生物不太可能对环境构成威胁,因为它们已经经过高度筛选,能够在有限的条件下生存。然而,在自然或半自然种群中进行新特性的工程设计可能会带来更大的风险。遗传新颖性,即突变,是进化过程的重要组成部分;一小部分自然突变会导致适应性提高和竞争力增强。人工插入一个新特性可能会产生类似的效果,使生物体走上一条新的、不可预测的进化轨道。目前的挑战是要具备识别可能发生这种情况的少数基因工程生物的能力。