Department of Medicine & Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong.
J Neurol Sci. 2011 Mar 15;302(1-2):108-11. doi: 10.1016/j.jns.2010.12.012. Epub 2011 Jan 12.
Patients with enteric fever frequently develop neurological complications during their illness. Among them, majority has encephalopathy, but focal deficits or peripheral nervous involvements are occasionally encountered. We describe a young woman who developed a neurological syndrome consistent with Bickerstaff's brainstem encephalitis, with symptoms and signs including convulsion, impaired consciousness, external ophthalmoplegia, ataxia, bulbar palsy and pyramidal signs, following Salmonella Paratyphi A infection. This is the first case report of this syndrome after S. Paratyphi A infection, and it is the second case of Bickerstaff's brainstem encephalitis complicating enteric fever reported in the literature. This case also demonstrated, for the first time, a positive anti-GQ1b IgG response in a patient with Bickerstaff's brainstem encephalitis and related disorders that appear as complications during enteric fever.
肠热病患者在发病过程中常发生神经系统并发症。其中，多数为脑病，但偶尔也会出现局灶性缺损或周围神经受累。我们描述了一位年轻女性，她在感染甲型副伤寒沙门氏菌后出现了符合 Bickerstaff 脑干脑炎的神经系统综合征，症状和体征包括癫痫发作、意识障碍、外展神经麻痹、共济失调、球麻痹和锥体束征。这是甲型副伤寒沙门氏菌感染后该综合征的首例报告，也是文献中报道的第 2 例肠热病并发 Bickerstaff 脑干脑炎。该病例还首次在肠热病相关并发症中出现 Bickerstaff 脑干脑炎及相关疾病患者抗 GQ1b IgG 阳性反应。
