Academic Research and Information Management, Uppsala, Sweden.
Helicobacter. 2011 Feb;16(1):1-8. doi: 10.1111/j.1523-5378.2010.00812.x.
Helicobacter pylori infection is regarded as the major cause of various gastric diseases and induces the production of several cytokines including interleukin-17 (IL-17) recently recognized as an important player in the mammalian immune system.
This review deals with the role of IL-17 on the H. pylori-induced infection and immunity in humans and experimental animals.
H. pylori infection increases IL-17 in the gastric mucosa of humans and experimental animals. In humans, IL-17 induces the secretion of IL-8 by activating the ERK 1/2 MAP kinase pathway and the released IL-8 attracts neutrophils promoting inflammation. IL-23 is increased in patients with H. pylori-related gastritis and regulates IL-17 secretion via STAT3 pathway. Studies in H. pylori-infected mice indicate that IL-17 is primarily associated with gastric inflammation. The early events in the immune response of immunized and challenged mice include the recruitment of T cells and the production of IL-17. Neutrophil attracting chemokines are released, and the bacterial load is considerably reduced. IL-17 plays a dual role in infection and vaccination. In infection, T regulatory cells (Tregs) suppress the inflammatory reaction driven by IL-17 thereby favoring bacterial persistence. Immunization produces Helicobacter-specific memory T-helper cells that can possibly alter the ratio between T-helper 17 and Treg responses so that the IL-17-driven inflammatory reaction can overcome the Treg response leading to bacterial clearance.
IL-17 plays an important role in H. pylori-related gastritis and in the reduction of Helicobacter infection in mice following immunization.
幽门螺杆菌感染被认为是各种胃病的主要原因，最近发现它会产生几种细胞因子，包括白细胞介素-17（IL-17），白细胞介素-17 被认为是哺乳动物免疫系统中的重要成员。
本文综述了白细胞介素-17 在人类和实验动物的幽门螺杆菌感染和免疫中的作用。
幽门螺杆菌感染会增加人类和实验动物胃黏膜中的白细胞介素-17。在人类中，白细胞介素-17 通过激活 ERK 1/2 MAP 激酶通路诱导 IL-8 的分泌，释放的 IL-8 吸引中性粒细胞，促进炎症。与幽门螺杆菌相关胃炎患者的白细胞介素-23 增加，并通过 STAT3 通路调节白细胞介素-17 的分泌。在幽门螺杆菌感染的小鼠研究中，白细胞介素-17 主要与胃炎症相关。免疫和挑战小鼠的早期免疫反应事件包括 T 细胞的募集和白细胞介素-17 的产生。中性粒细胞趋化因子释放，细菌负荷量显著降低。白细胞介素-17 在感染和疫苗接种中发挥双重作用。在感染中，调节性 T 细胞（Tregs）抑制白细胞介素-17 驱动的炎症反应，从而有利于细菌的持续存在。免疫接种产生的幽门螺杆菌特异性记忆辅助性 T 细胞可能会改变辅助性 T 细胞 17 和 Treg 反应之间的比例，使白细胞介素-17 驱动的炎症反应能够克服 Treg 反应，从而导致细菌清除。
白细胞介素-17 在幽门螺杆菌相关性胃炎以及免疫接种后小鼠的幽门螺杆菌感染减少中发挥重要作用。
