Max-Planck-Institute of Immunobiology und Epigenetics, Stübeweg 51,79108 Freiburg im Breisgau, Germany.
Curr Opin Cell Biol. 2011 Jun;23(3):346-53. doi: 10.1016/j.ceb.2010.12.005. Epub 2011 Jan 15.
Nuclear pore complexes play a central role in controlling the traffic between the nucleus and the cytoplasm. Progress during the last decade has highlighted nuclear periphery components as novel players in chromatin organization, gene regulation, and genome stability. For instance, lamins associate with repressive chromatin while nuclear pores tend to associate with active chromatin. Interestingly, nucleoporins (Nups) act not only at the nuclear periphery but also in the nucleoplasm. Here we provide an overview of the latest findings and discuss the functional importance of nucleoporin association with specific genes, their role in transcriptional memory, the coupling of transcription and mRNA export, and genome integrity.
核孔复合物在控制核质间物质运输中起着核心作用。过去十年的研究进展强调了核周成分在染色质组织、基因调控和基因组稳定性方面的新作用。例如，核纤层与抑制性染色质相关，而核孔倾向于与活性染色质相关。有趣的是，核孔蛋白（Nups）不仅在核周发挥作用，也在核质中发挥作用。在这里，我们概述了最新的发现，并讨论了核孔蛋白与特定基因结合的功能重要性、它们在转录记忆中的作用、转录和 mRNA 输出的偶联以及基因组完整性。
