Department of Pharmacology, UC Davis School of Medicine, Davis, CA 95616, United States.
Curr Opin Neurobiol. 2011 Apr;21(2):221-7. doi: 10.1016/j.conb.2010.12.005. Epub 2011 Jan 15.
Synapses are specialized cell-cell adhesion contacts that mediate communication within neural networks. During development, excitatory synapses are generated by step-wise recruitment of presynaptic and postsynaptic proteins to sites of contact. Several classes of synaptic organizing complexes have been identified that function during the initial stages of synapse formation. However, mechanisms underlying the later stages of synapse development are less well understood. In recent years, molecules have been discovered that appear to play a role in synapse maturation. In this review, we highlight recent findings that have provided key insights for understanding postsynaptic maturation of developing excitatory synapses with a focus on recruitment of AMPA receptors to developing synapses.
突触是细胞间特化的黏附接触，介导神经网络内的通讯。在发育过程中，兴奋性突触通过逐步募集突触前和突触后蛋白到接触部位而产生。已经鉴定出几类在突触形成的初始阶段起作用的突触组织复合物。然而，突触发育后期的机制尚不清楚。近年来，发现了一些似乎在突触成熟中起作用的分子。在这篇综述中，我们强调了最近的发现，这些发现为理解发育中兴奋性突触的突触后成熟提供了关键的见解，重点是 AMPA 受体向发育中的突触募集。
