Gaball Curtis, Lovald Scott, Baack Bret, Olson Garth
Ear, Nose and Throat Department, Naval Medical Center San Diego, 34520 Bob Wilson Dr, San Diego, CA 92130, USA.
Arch Facial Plast Surg. 2011 Jan-Feb;13(1):31-5. doi: 10.1001/archfacial.2010.109.
To optimize design variables of a bioabsorbable bone plate using a finite element model of the mandible and to discover a minimally invasive bioabsorbable bone plate design that can provide the same mechanical stability as a titanium plate.
A finite element model of a mandible with a fracture in the body was subjected to bite loads. An analysis was run to determine the principal strain in the fracture callus and von Mises stress in a titanium plate. These values were then set as the limits within which the bioabsorbable bone plate must comply. The model then considered a bone plate made of the polymer poly(L-lactide-co-D,L-lactide) (P[L/DL]LA) 70/30. An optimization routine determined the smallest volume of bioabsorbable bone plate that can perform as well as a titanium bone plate when fixating mandibular fractures.
A P(L/DL)LA plate volume of 315 mm(2) with a thickness of 1.5 mm provided as much mechanical stability as a commonly used titanium strut structure of 172 mm(2). The peak plate stress was well below the yield strength of the material.
The P(L/DL)LA bioabsorbable bone plate design is as strong as a titanium plate when fixating fractures of the mandible body despite the polymer material having only 6% of the stiffness of the titanium. The P(L/DL)LA plate can be less than half the volume of its strut-style counterpart.
利用下颌骨有限元模型优化生物可吸收接骨板的设计变量，以探寻一种微创生物可吸收接骨板设计，使其能提供与钛板相同的机械稳定性。
对下颌骨体部骨折的有限元模型施加咬合负荷。进行分析以确定骨折骨痂中的主应变和钛板中的冯·米塞斯应力。然后将这些值设定为生物可吸收接骨板必须符合的限度。该模型接着考虑由聚（L-丙交酯-co-D,L-丙交酯）（P[L/DL]LA）70/30制成的接骨板。一个优化程序确定了在下颌骨骨折固定时性能与钛接骨板相当的最小体积生物可吸收接骨板。
一块厚度为1.5毫米、体积为315立方毫米的P（L/DL）LA接骨板提供的机械稳定性与一块常用的172立方毫米钛支柱结构接骨板相当。接骨板的峰值应力远低于材料的屈服强度。
尽管聚合物材料的刚度仅为钛的6%，但在固定下颌骨体部骨折时，P（L/DL）LA生物可吸收接骨板设计与钛板一样坚固。P（L/DL）LA接骨板的体积可小于其支柱式对应接骨板的一半。
