Sezer Engin, Luzar Bostjan, Calonje Eduardo
Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
J Cutan Pathol. 2011 May;38(5):439-42. doi: 10.1111/j.1600-0560.2010.01657.x. Epub 2011 Jan 19.
A granulomatous tissue response may be observed in untreated, long-standing lesions of secondary syphilis. In addition to poorly defined granulomatous inflammation, leprosy-like sarcoidal and palisaded granulomatous inflammation has been documented in literature reports of lues. Herein, we report a 47-year-old man who presented with a 3-month history of a generalized non-pruritic macular and papular rash located on the trunk and extremities. Histopathologically, there was an interstitial arrangement of histiocytes with occasional multinucleated giant cells positioned among collagen bundles without associated necrosis, thereby closely mimicking interstitial granuloma annulare. A clue to the diagnosis was the presence of admixed plasma cells. To the best of our knowledge, this is the first reported case of secondary syphilis showing an interstitial granulomatous pattern mimicking interstitial granuloma annulare.
在未经治疗的二期梅毒长期病变中可观察到肉芽肿组织反应。除了界限不清的肉芽肿性炎症外，文献报道的梅毒病例中还出现了类麻风结节病样和栅栏状肉芽肿性炎症。在此，我们报告一名47岁男性，其躯干和四肢出现泛发性非瘙痒性斑疹和丘疹3个月。组织病理学检查显示，组织细胞呈间质排列，偶见多核巨细胞位于胶原束之间，无相关坏死，酷似环状肉芽肿。诊断的线索是混有浆细胞。据我们所知，这是首例报告的表现为酷似环状肉芽肿的间质肉芽肿模式的二期梅毒病例。
