Sturesson Christian, Ivarsson Kjell, Stenram Unne, Andersson-Engels Stefan, Tranberg Karl-Göran
Department of Surgery, Clinical Sciences Lund, Lund University, SE-221 85 Lund, Sweden.
Lasers Surg Med. 2011 Jan;43(1):29-35. doi: 10.1002/lsm.21024.
Interstitial laser thermotherapy was used to treat rat liver tumours. The aim was to investigate the influence of temperature and temporary hepatic inflow occlusion on tumour growth and blood perfusion.
STUDY DESIGN/MATERIALS AND METHODS: Liver tumours were treated at 44°C at the tumour border for 30 minutes, hepatic inflow occlusion only, or a combination of these methods. Interstitial laser Doppler flowmetry was used to measure hepatic perfusion at the tumour border during and after heat treatment, for a total time of 60 minutes. Tumour growth was evaluated 6 days after treatment.
Tumours subjected to the combined treatment of hepatic inflow occlusion and interstitial laser thermotherapy displayed a blood perfusion reduction 30 minutes after treatment to 18 ± 5% of initial perfusion, which was significantly lower than achieved with thermotherapy alone (52 ± 10%, P = 0.02). The combined treatment and treatment with thermotherapy alone resulted in relative tumour growth of 0.3 ± 0.1 and 1.0 ± 0.2, respectively (P = 0.04).
Inflow occlusion enhanced the effect of thermotherapy not by augmenting treatment temperatures but by increasing the thermal sensitivity of the tumour, reflected by an immediate effect on tumour blood perfusion.
采用间质激光热疗治疗大鼠肝肿瘤。目的是研究温度和暂时性肝血流阻断对肿瘤生长和血液灌注的影响。
研究设计/材料与方法：在肿瘤边缘44°C下对肝肿瘤进行30分钟治疗、仅进行肝血流阻断或采用这些方法的联合治疗。在热处理期间和之后，使用间质激光多普勒血流仪测量肿瘤边缘的肝灌注，总时长为60分钟。在治疗6天后评估肿瘤生长情况。
接受肝血流阻断与间质激光热疗联合治疗的肿瘤在治疗30分钟后血液灌注降低至初始灌注的18±5%，这显著低于仅采用热疗的情况（52±10%，P = 0.02）。联合治疗和仅采用热疗分别导致肿瘤相对生长为0.3±0.1和1.0±0.2（P = 0.04）。
血流阻断增强了热疗效果，并非通过提高治疗温度，而是通过增加肿瘤的热敏感性，这表现为对肿瘤血液灌注的即时影响。
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