蛋白C、蛋白S和抗凝血酶缺乏以及活化蛋白C抵抗——它们与动脉血栓形成的关系。
Deficiencies of proteins C, S and antithrombin and activated protein C resistance--their involvement in the occurrence of Arterial thromboses.
作者信息
Soare Angela Mirela, Popa Constantin
机构信息
Neurology Clinic, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania.
出版信息
J Med Life. 2010 Oct-Dec;3(4):412-5.
Deficiencies of natural anticoagulants protein C, protein S, antithrombin and activated protein C resistance are components of inherited thrombophilia. Inherited thrombophilia was defined as a genetically determined tendency towards venous thromboembolism, which characteristically occurs in young patients (before 40 to 45 years old), without apparent causes, and tend to recur. There have been many debates about the implication of these defects in arterial thromboses (peripheral artery disease, myocardial infarction, cerebral infarction) in the recent years. The screening for thrombophilia is recommended for young patients with spontaneous thromboses, arterial infarctions, family history of thromboses, personal history of recurrent abortions, with thrombosis of venous dural sinuses or strokes or myocardial infarctions, in patients with venous thrombosis in unusual sites, because the diagnosis of such a disease leads to a treatment that is lifesaving [1,2].
天然抗凝蛋白C、蛋白S、抗凝血酶缺乏以及活化蛋白C抵抗是遗传性易栓症的组成部分。遗传性易栓症被定义为一种由基因决定的发生静脉血栓栓塞的倾向，其特征是发生在年轻患者（40至45岁之前），无明显病因，且易于复发。近年来，关于这些缺陷在动脉血栓形成（外周动脉疾病、心肌梗死、脑梗死）中的意义存在诸多争论。对于有自发血栓形成、动脉梗死、血栓形成家族史、反复流产个人史、静脉硬脑膜窦血栓形成或中风或心肌梗死的年轻患者，对于静脉血栓形成部位不寻常的患者，建议进行易栓症筛查，因为诊断出这种疾病会带来挽救生命的治疗方法[1,2]。
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