Van Craeyveld Eline, Gordts Stephanie C, Jacobs Frank, De Geest Bart
Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Heart Vessels. 2012 Mar;27(2):231-4. doi: 10.1007/s00380-010-0098-9. Epub 2011 Jan 26.
There is a surprising paucity of studies that provide quantitative correlative data on the extent of atherosclerosis between different topographic sites. The impact of cardiovascular risk factors is dependent on the vascular bed, which underlies site-selective effects on progression of atherosclerosis. Therefore, the intraindividual correlation of atherosclerosis between different topographic sites may be dependent on the specific cardiovascular risk profile. The focused objective of the current study is to evaluate whether the correlation of the extent of atherosclerosis between different topographic sites is dependent on the type of hyperlipidemia. Atherosclerosis was quantified at four different topographic locations in the aorta of rabbits with type II or type III hyperlipidemia. Correlation coefficients and semi-partial correlation coefficients adjusted for plasma lipoproteins and sex were determined to compare the degree of atherosclerosis at different topographic sites. Semi-partial correlations adjusted for total plasma cholesterol, plasma triglycerides, and sex of the intima/media ratio between different topographic sites were highly dependent on the type of hyperlipidemia. E.g., the semi-partial correlation coefficient between the intima/media ratio at the level of the ascending aorta and at the level of the descending thoracic aorta was 0.87 (p < 0.0001) in the model of type II hyperlipidemia and was only 0.10 (p = NS) in the model of type III hyperlipidemia. This divergent pattern was also observed for other intersite correlations. Semi-partial Pearson correlation coefficients were very similar to unadjusted Pearson correlation coefficients. Correlation of atherosclerosis between different topographic sites may vary importantly in relation to the type of hyperlipidemia.
令人惊讶的是,很少有研究提供不同解剖部位动脉粥样硬化程度的定量相关数据。心血管危险因素的影响取决于血管床,这是动脉粥样硬化进展存在部位选择性效应的基础。因此,不同解剖部位之间动脉粥样硬化的个体内相关性可能取决于特定的心血管风险状况。本研究的重点目标是评估不同解剖部位之间动脉粥样硬化程度的相关性是否取决于高脂血症的类型。对患有II型或III型高脂血症的兔子主动脉的四个不同解剖位置的动脉粥样硬化进行了量化。确定了针对血浆脂蛋白和性别进行调整的相关系数和半偏相关系数,以比较不同解剖部位的动脉粥样硬化程度。针对不同解剖部位之间内膜/中膜比值,根据总血浆胆固醇、血浆甘油三酯和性别进行调整后的半偏相关性高度取决于高脂血症的类型。例如,在II型高脂血症模型中,升主动脉水平与胸降主动脉水平的内膜/中膜比值之间的半偏相关系数为0.87(p < 0.0001),而在III型高脂血症模型中仅为0.10(p = 无显著性差异)。其他部位间相关性也观察到这种不同的模式。半偏Pearson相关系数与未调整的Pearson相关系数非常相似。不同解剖部位之间动脉粥样硬化的相关性可能因高脂血症类型的不同而有很大差异。