黏膜类天疱疮，免疫球蛋白 G 自身抗体针对 BP180 的全长和 120kDa 细胞外结构域。

Mucous membrane pemphigoid with immunoglobulin G autoantibodies against full-length and 120-kDa ectodomain of BP180.

机构信息

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.

出版信息

J Dermatol. 2011 Feb;38(2):169-72. doi: 10.1111/j.1346-8138.2010.01072.x. Epub 2010 Nov 23.

DOI:10.1111/j.1346-8138.2010.01072.x

PMID:21269314

Abstract

Mucous membrane pemphigoid (MMP) is a rare autoimmune, subepidermal, bullous disease characterized by erosive lesions on the mucous membranes and skin. MMP reacts with various target antigens including BP180, laminin-332, β4 integrin, α6 integrin or type VII collagen. We present a 67-year-old male MMP patient who had lesions on the oral and ocular mucous membranes and facial skin. By immunoblot analyses, immunoglobulin G autoantibodies in the patient's sera reacted with full-length BP180 and the 120-kDa ectodomain of BP180 (LAD-1).

摘要

黏膜类天疱疮（Mucous membrane pemphigoid，MMP）是一种罕见的自身免疫性、表皮下、大疱性疾病，其特征为黏膜和皮肤的侵蚀性病变。MMP 与各种靶抗原反应，包括 BP180、层粘连蛋白-332、β4 整合素、α6 整合素或 VII 型胶原。我们报告了一例 67 岁男性 MMP 患者，他患有口腔和眼部黏膜及面部皮肤病变。通过免疫印迹分析，患者血清中的 IgG 自身抗体与全长 BP180 和 BP180 的 120-kDa 细胞外结构域（LAD-1）反应。