[与颞叶癫痫相关基因的生物信息学分析]
[Bioinformatic analysis of genes related to temporal epilepsy].
作者信息
Zhou Ye, Shi Rong, Bao Yong, Li Chang-zheng, Xie Wei, Zheng Wen-ling, Ma Wen-li
机构信息
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jan;31(1):180-3.
OBJECTIVE
To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy.
METHODS
The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.
RESULTS
Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc.
CONCLUSION
The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.
目的
研究与颞叶癫痫相关的基因，并探索癫痫的分子机制。
方法
从基因表达综合数据库（GEO）下载颞叶癫痫的微阵列数据，并使用String、KEGG和Panther数据库通过生物信息学方法进行分析。
结果
在所有71个差异表达基因中，发现51个基因编码具有相互作用的蛋白质；主要涉及的生物学途径包括神经活性配体-受体相互作用、MAPK信号通路和钙信号通路等。
结论
癫痫的发病机制涉及多个基因，对这些基因的研究可能为癫痫的机制提供有价值的见解。
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