Texas Heart Institute at St Luke's Episcopal Hospital, Houston, TX, USA.
Eur J Cardiothorac Surg. 2011 Jul;40(1):227-32. doi: 10.1016/j.ejcts.2010.11.005. Epub 2011 Jan 26.
Off-pump coronary artery bypass surgery (OPCAB) and beating-heart coronary artery bypass grafting (BH-CAB) performed with cardiopulmonary bypass support are used with increasing frequency in the treatment of coronary artery occlusive disease. The utility of OPCAB and BH-CAB in treating high-risk patients has been studied, but the effects of these procedures on ventricular function have not been thoroughly investigated.
Data were collected from a database encompassing all patients who underwent isolated coronary revascularization performed by a single surgeon between August 2002 and March 2007. All procedures (n = 507) began as OPCAB operations, but 99 were converted to BH-CAB during surgery. Each patient's ejection fraction (EF) was measured preoperatively and postoperatively (median, 5.0 days after surgery).
We found that although the BH-CAB patients tended to be in worse health and to have a lower preoperative EF than the OPCAB patients, both groups of patients had similar improvements in postoperative EF (6.8% vs 5.4%; p = 0.65). In addition, multivariable linear regression showed that a lower preoperative EF, age ≥ 70 years, and cardiomegaly predicted less postoperative EF improvement after coronary revascularization by either OPCAB or BH-CAB.
Both OPCAB and BH-CAB procedures produce significant and similar short-term improvement in EF in patients with coronary disease. This change in EF may account for the subjective clinical improvements seen early after both procedures.
非体外循环冠状动脉旁路移植术(OPCAB)和在体外循环支持下进行的心脏不停跳冠状动脉旁路移植术(BH-CAB)在治疗冠状动脉闭塞性疾病中的应用频率越来越高。已经研究了 OPCAB 和 BH-CAB 在治疗高危患者中的应用,但这些手术对心室功能的影响尚未得到彻底研究。
从 2002 年 8 月至 2007 年 3 月期间由一位外科医生进行的所有接受孤立性冠状动脉血运重建的患者的数据库中收集数据。所有手术(n=507)均开始为 OPCAB 手术,但 99 例在手术过程中转为 BH-CAB。每位患者的射血分数(EF)在术前和术后(中位数为手术后 5.0 天)进行测量。
我们发现,尽管 BH-CAB 患者的健康状况往往较差,术前 EF 较低,但两组患者术后 EF 的改善相似(6.8%比 5.4%;p=0.65)。此外,多元线性回归显示,术前 EF 较低、年龄≥70 岁和心胸比增大预测了 OPCAB 或 BH-CAB 冠状动脉血运重建后 EF 改善较少。
OPCAB 和 BH-CAB 手术均可显著改善冠心病患者的 EF,并具有相似的短期效果。EF 的这种变化可能解释了两种手术后早期出现的主观临床改善。