通过 RNAi 筛选揭示流感病毒复制的全球宿主细胞需求。
Uncovering the global host cell requirements for influenza virus replication via RNAi screening.
机构信息
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
出版信息
Microbes Infect. 2011 May;13(5):516-25. doi: 10.1016/j.micinf.2011.01.012. Epub 2011 Jan 27.
Abstract
Influenza virus is reliant on numerous host cell functions during its replication cycle. RNA interference technology, applied on a genome-wide level, has identified human host factors that are necessary for efficient virus replication and provides new insight into how influenza virus interacts with its host at the molecular level.
摘要
流感病毒在其复制周期中依赖于许多宿主细胞功能。应用于全基因组水平的 RNA 干扰技术已经鉴定出了人类宿主因子，这些因子对于病毒的有效复制是必需的，并提供了新的见解，了解流感病毒如何在分子水平上与宿主相互作用。
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