Länger F, Puls F, Buchholz S, Loddenkemper C, Ganser A, Kreipe H
Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Pathologe. 2011 Mar;32(2):144-51. doi: 10.1007/s00292-010-1408-9.
Graft-versus-host disease (GvHD) occurs as a major complication in 35%-50% of all patients undergoing allogeneic stem cell transplantation. A distinction is made between acute and chronic GvHD depending on the time of onset, type of clinical symptoms and histology. Both forms preferably show manifestations in the skin, mucosal membranes, gastrointestinal tract, liver and (less often) lung. As the clinical presentation is rather unspecific, particularly for the diagnosis of acute GvHD, histology is important to exclude infectious diseases or drug reactions. This review covers the diagnostic morphological criteria and differential diagnoses of GvHD in the skin, gastrointestinal tract and the liver.
移植物抗宿主病（GvHD）是35%-50%接受异基因干细胞移植的患者出现的主要并发症。根据发病时间、临床症状类型和组织学，可区分急性和慢性GvHD。两种形式均主要在皮肤、粘膜、胃肠道、肝脏（较少见肺）出现表现。由于临床表现相当不具特异性，尤其是对于急性GvHD的诊断，组织学对于排除感染性疾病或药物反应很重要。本综述涵盖了皮肤、胃肠道和肝脏中GvHD的诊断形态学标准及鉴别诊断。
