Portinaro Nicola M A, Porteous Andrew, Parafioriti Antonina, Panou Artemisia, Benson Michael K D
Università degli Studi di Milano, Istituto Clinico Humanitas, Rozzano, Milan, Italy.
Hip Int. 2011 Jan-Mar;21(1):9-13. doi: 10.5301/hip.2011.6310.
There are no clear explanations for the spectrum of hip dysplasia nor for the observation that in normal and dysplastic hips, final development may be unpredictable with or without treatment. Immunohistochemical and histological studies of a three month old child's acetabulae were performed. Multiple inclusions were found in the lateral ring epiphysis and in the three flanges of the triradiate cartilage. These inclusions may represent cartilage vessel systems pre-destined to form the secondary centres of ossification. Damage to the primary acetabular growth plates may occur congenitally and help to explain the spectrum of acetabular dysplasia. Damage to one or more of these centres, whether due to instability, displacement or iatrogenic injury, may cause failure of late acetabular development. Hips at risk of damage to the acetabular cartilages should be followed up longer.
对于髋关节发育不良的范围，以及在正常和发育不良的髋关节中，无论是否接受治疗最终发育都可能不可预测这一现象，目前尚无明确解释。对一名三个月大儿童的髋臼进行了免疫组织化学和组织学研究。在外侧环状骨骺和髋臼软骨的三个翼中发现了多个包涵体。这些包涵体可能代表了注定要形成继发骨化中心的软骨血管系统。原发性髋臼生长板可能会先天性受损，这有助于解释髋臼发育不良的范围。这些中心中的一个或多个受到损伤，无论是由于不稳定、移位还是医源性损伤，都可能导致髋臼后期发育失败。有髋臼软骨损伤风险的髋关节应进行更长时间的随访。
