人类 IRGM1 的多态性等位基因与非裔美国人的结核病易感性相关。
Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.
机构信息
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America.
出版信息
PLoS One. 2011 Jan 21;6(1):e16317. doi: 10.1371/journal.pone.0016317.
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
人类自噬相关基因 IRGM1 的一个祖先多态性等位基因与基因表达改变和克罗恩病 (CD) 的遗传风险相关。我们使用单核苷酸多态性 rs10065172C/T 作为该多态性等位基因的标记，并对 370 名非裔美国人和 177 名白种人结核病 (TB) 病例和 180 名非裔美国人和 110 名白种人对照进行了基因分型。在非裔美国人中，与对照组相比，结核病病例更有可能携带与 CD 相关的 rs10065172T 等位基因（比值比为 1.54；95%置信区间为 1.17-2.02；P<0.01）。我们的发现表明，与 CD 相关的 IRGM1 多态性等位基因也与非裔美国人中人类对结核病的易感性相关。
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